From Illinois State Police:
Update: As of 4:40 p.m. Southbound lanes are back open, while Northbound lanes remain closed at this time.
Earlier: As of 12:40 p.m. Friday, November 16th Troopers are en route to a head-on crash with serious injuries on U.S. Route 45 between Champaign County Road 2300 North and 2400 North. Air life is en route as well. The crash involves a garbage hauler and a passenger vehicle. The roadway is expected to closed for an extended period of time.
Please use caution and seek an alternate route if possible for the time being.